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Sweden-Nobel Prize/Physiology or Medicine
Stockholm, Sweden - Oct 7, 2019 (CCTV - No access Chinese mainland)
1. Press conference in progress
2. Photo showing Gregg L. Semenza (L), Sir Peter J. Ratcliffe (M), William G. Kaelin Jr (R), laureates for 2019 Nobel Prize in Physiology or Medicine
3. Press conference in progress
4. Audience
5. SOUNDBITE (English) Nils-Goran Larsson, professor in mitochondrial geneticsm, Department of Laboratory Medicine, Karolinska Institute (partially overlaid with shot 6):
"So this year's Nobel Prize is about a basic scientific discovery, about the regulatory system in our body that adapts metabolism to oxygen levels. And this system then can reprogram itself so that the metabolism can cope with different levels of oxygen, and it can also induce more red blood cells, and growth of blood vessels to oxygenate tissues. So it's a very important system and it's present in virtually all animals on the planet."
++SHOTS OVERLAYING SOUNDBITE++
6. Screen explaining discoveries by new Nobel laureates
++SHOTS OVERLAYING SOUNDBITE++
7. Various of guest delivering speech at press conference
8. Screen explaining discoveries by new Nobel laureates
9. SOUNDBITE (Chinese) Li Shuijie, postdoctoral researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute:
"We still have a long way to go to carry out relevant research, because the hypoxia inducible factor is not the only factor that can lead to cancer. So we still have a lot of work to do."
10. Various of guest delivering speech at press conference
11. Screen explaining discoveries by new Nobel laureates
12. Cameramen
Three scientists have shared 2019 Nobel Prize in Physiology or Medicine, the Nobel committee announced on Monday in Stockholm, Sweden.
The prize has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza "for their discoveries of how cells sense and adapt to oxygen availability," according to the Nobel assembly at the Karolinska Institute.
Animals need oxygen for the conversion of food into useful energy. The fundamental importance of oxygen has been understood for centuries, but how cells adapt to changes in levels of oxygen has long been unknown.
The three scientists have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen, the committee said.
"So this year's Nobel Prize is about a basic scientific discovery, about the regulatory system in our body that adapts metabolism to oxygen levels. And this system then can reprogram itself so that the metabolism can cope with different levels of oxygen, and it can also induce more red blood cells, and growth of blood vessels to oxygenate tissues. So it's a very important system and it's present in virtually all animals on the planet," said Nils-Goran Larsson, a professor in mitochondrial genetics at the Department of Laboratory Medicine at Karolinska Institute.
The discoveries made by the three scientists have fundamental importance for physiology and have paved the way for promising new strategies to fight anemia, cancer and many other diseases.
But as there are many factors that can lead to cancer, researchers still have a long way to go to fight the disease, according to Li Shuijie, a postdoctoral researcher at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institute.
"We still have a long way to go to carry out relevant research, because the hypoxia inducible factor is not the only factor that can lead to cancer. So we still have a lot of work to do," said Li.
Kaelin, born in New York, is an Investigator of the Howard Hughes Medical Institute since 1998. Semenza, also born New York, is the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering since 2003. Ratcliffe is the Director of Clinical Research at Francis Crick Institute, London, Director for Target Discovery Institute in Oxford and Member of the Ludwig Institute for Cancer Research.
This year's prize is nine million Swedish krona (about 907,752 U.S. dollars), which will be equally shared among three laureates.
Sweden-Nobel Prize/Physiology or Medicine
Dateline : Oct 7, 2019
Location : Stockholm,Sweden
Duration : 1'28
Stockholm, Sweden - Oct 7, 2019 (CCTV - No access Chinese mainland)
1. Press conference in progress
2. Photo showing Gregg L. Semenza (L), Sir Peter J. Ratcliffe (M), William G. Kaelin Jr (R), laureates for 2019 Nobel Prize in Physiology or Medicine
3. Press conference in progress
4. Audience
5. SOUNDBITE (English) Nils-Goran Larsson, professor in mitochondrial geneticsm, Department of Laboratory Medicine, Karolinska Institute (partially overlaid with shot 6):
"So this year's Nobel Prize is about a basic scientific discovery, about the regulatory system in our body that adapts metabolism to oxygen levels. And this system then can reprogram itself so that the metabolism can cope with different levels of oxygen, and it can also induce more red blood cells, and growth of blood vessels to oxygenate tissues. So it's a very important system and it's present in virtually all animals on the planet."
++SHOTS OVERLAYING SOUNDBITE++
6. Screen explaining discoveries by new Nobel laureates
++SHOTS OVERLAYING SOUNDBITE++
7. Various of guest delivering speech at press conference
8. Screen explaining discoveries by new Nobel laureates
9. SOUNDBITE (Chinese) Li Shuijie, postdoctoral researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute:
"We still have a long way to go to carry out relevant research, because the hypoxia inducible factor is not the only factor that can lead to cancer. So we still have a lot of work to do."
10. Various of guest delivering speech at press conference
11. Screen explaining discoveries by new Nobel laureates
12. Cameramen
Three scientists have shared 2019 Nobel Prize in Physiology or Medicine, the Nobel committee announced on Monday in Stockholm, Sweden.
The prize has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza "for their discoveries of how cells sense and adapt to oxygen availability," according to the Nobel assembly at the Karolinska Institute.
Animals need oxygen for the conversion of food into useful energy. The fundamental importance of oxygen has been understood for centuries, but how cells adapt to changes in levels of oxygen has long been unknown.
The three scientists have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen, the committee said.
"So this year's Nobel Prize is about a basic scientific discovery, about the regulatory system in our body that adapts metabolism to oxygen levels. And this system then can reprogram itself so that the metabolism can cope with different levels of oxygen, and it can also induce more red blood cells, and growth of blood vessels to oxygenate tissues. So it's a very important system and it's present in virtually all animals on the planet," said Nils-Goran Larsson, a professor in mitochondrial genetics at the Department of Laboratory Medicine at Karolinska Institute.
The discoveries made by the three scientists have fundamental importance for physiology and have paved the way for promising new strategies to fight anemia, cancer and many other diseases.
But as there are many factors that can lead to cancer, researchers still have a long way to go to fight the disease, according to Li Shuijie, a postdoctoral researcher at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institute.
"We still have a long way to go to carry out relevant research, because the hypoxia inducible factor is not the only factor that can lead to cancer. So we still have a lot of work to do," said Li.
Kaelin, born in New York, is an Investigator of the Howard Hughes Medical Institute since 1998. Semenza, also born New York, is the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering since 2003. Ratcliffe is the Director of Clinical Research at Francis Crick Institute, London, Director for Target Discovery Institute in Oxford and Member of the Ludwig Institute for Cancer Research.
This year's prize is nine million Swedish krona (about 907,752 U.S. dollars), which will be equally shared among three laureates.
ID : 8123779
Published : 2019-10-08 07:06
Last Modified : 2019-10-08 20:42:00
Source : China Central Television (CCTV)
Restrictions : No access Chinese mainland
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